Compare the Audi R8 5.2 V10 Spyder - [2012] vs Mercedes S Class 65 AMG 6.0 V12 - [2017]. Find out which car is the fastest, most powerful, lightest or has the biggest engine in our top trumps style comparison page. Find out which car has the highest top speed or is the fastest accelerating, is it the Audi R8 5.2 V10 Spyder or the Mercedes S Class 65 AMG 6.0 V12. We'll leave it up to you to decide which is your favourite.